Aung San Suu Kyi, whose party won a landslide victory in elections last month, is set to meet President Thein Sein to discuss the handover of power.
She will also separately meet Commander-in-Chief Min Aung Hlaing.
Both men have pledged to assist in a smooth transfer of power after decades of military rule.
Ms Suu Kyi is constitutionally barred from becoming president- but has said she will be above the person she nominates for the role.
She cannot become president because her two sons have foreign nationality. They, like their late father, are British.
She led the National League for Democracy (NLD) to victory in 8 November polls, the most democratic elections in Myanmar in 25 years.
The details of the talks are not expected to be released until nearer their conclusion.
The army retains a quarter of the seats in both the upper and lower house of parliament. It ruled Myanmar, also known as Burma, with an iron fist from 1962 until 2011.
In 2011, a military-backed civilian government came into power led by Thein Sein.
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